Compressed gas cylinders contain varying pressures of inert, toxic, flammable, oxidizing, corrosive, or combinations of gases.  Care in using, handling, and storing compressed gas cylinders is required due to the high potential for severe incident. 

Know gas properties and hazards:  Understand the properties, uses, and safety precautions before using any gas or mixture.  Consult SDS and manufacturer specification sheets for safety information. 

Engineer, assemble, and check equipment properly:  Ensure that valves, manifolds, piping, lines, and other equipment is designed and rated for the full pressure and temperature range of operation.  Only use fittings as they are specified for by the manufacturer.  Inspect and leak check all equipment for using at full capacity. 

Utilize facilities engineering:  Gas cabinets, facilities exhaust, and fume hoods may be needed for ventilation.  Gas cylinder brackets, clamps, restraints and supports may be needed for storage.  Monitoring systems may be appropriate for highly hazardous gases. 

Wear PPE:  Wear suitable protective clothing and equipment.  Gloves, eye and face protection, and footwear may be warranted.  Some gases may require specialized safety equipment such as self-contained breathing apparatus, air-line respirators. 

Follow Regulations:  Follow all federal, state, and local regulations that apply to storage and use of compressed gas cylinders.